DPC-681 - 10mM in DMSO , CAS No.284661-68-3

CAS: 284661-68-3 Cat. No.: D655531 分子式: C₃₅H₄₈FN₅O₅S 分子量: 669.85 PubChem CID: 3083536

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.IC50 value: 4 - 40 nM Target: HIV protease in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions.in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog.

IC50& Target:HIV-1

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.\nIC50 value: 4 - 40 nM \nTarget: HIV protease in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1 . When all of the HIV-1 strains t

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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アクションタイプ

INHIBITOR

名前と識別子

• 異性体SMILES: CC(C)CN(CC([C@H](CC1=CC=CC=C1)N(CC2=CC(=CC=C2)F)[C@@H](C(=O)NC(=O)CN)C(C)(C)C)O)S(=O)(=O)C3=CC=CC(=C3)N
• 代替CAS番号: 284661-68-3
• PubChem CID: 3083536
• MeSH用語: DPC 681
• 分子量: 669.85