DRB18 - ≥98% , CAS No.D414435

CAS: D414435 Cat. No.: D414435 分子式: C₂₂H₂₃ClN₂O₂ 分子量: 382.88

グレード＆純度 ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Information

DRB18 DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

Targets

GLUT

In vitro

DRB18 inhibits growth and proliferation in about 90% of the 60 different cancer cell lines in 9 major cancer types. DRB18 treatment leads to significant changes in glucose-based metabolism in A549 lung cancer cells, including cell death via ER/oxidative stress and necrosis.

In vivo

DRB18 (10 mg/kg) treatment thrice a week significantly reduces growth in Xenograft A549 tumors.

仕様

仕様と純度

≥98%

生化学的・生理学的メカニズム

DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

製品の性質

ALogP

5.767

HBD数

4

回転可能な結合

6

名前と識別子

カノニカル・スマイル

CC1=CC=C(CNC2=C(NCC3=CC(=C(C)C=C3)O)C=C(Cl)C=C2)C=C1O

分子量

382.88

Reaxy-Rn

36374407

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36374407&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 76 mg/mL (198.49 mM); Ethanol: 76 mg/mL (198.49 mM); Water: Insoluble
• DMSO（mg / mL） 最大溶解度: 76
• DMSO（mM） 最大溶解度: 198.495612202257
• 水（mg / mL） 最大溶解度: ＜1

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is D414435, the molecular formula is C22H23ClN2O2, and the molecular weight is 382.88 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.