DRF-1042 - 10mM in DMSO , CAS No.200619-13-2

CAS: 200619-13-2 Cat. No.: D655919 分子式: C₂₂H₂₀N₂O₆ 分子量: 408.40 PubChem CID: 23631031

グレード＆純度 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype

In Vitro

DRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:DNA topoisomerase I

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype.

保管条件

Argon charged,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

CC[C@@]1(C2=C(COC1=O)C(=O)N3C(C4=CC5=CC=CC=C5N=C4C3=C2)OCCO)O

代替CAS番号

200619-13-2

PubChem CID

23631031

MeSH用語

5-(2'-hydroxyethoxy)-20(S)-camptothecin;DRF-1042;DRF1042

分子量

408.40