Dronedarone HCl - 10mM in DMSO , Voltage-gated L-type calcium channel blocker, CAS No.141625-93-6, Voltage-gated L-type calcium channel blocker

CAS: 141625-93-6 Cat. No.: D408521 分子式: C₃₁H₄₄N₂O₅S·HCl 分子量: 593.22 EC番号: 630-355-2

GRADE & PURITY 10mM in DMSO

Synonyms

SR33589 | N-​[2-​butyl-​3-​[4-​[3-​(dibutylamino)​propoxy]​benzoyl]​-​5-​benzofuranyl]​-methanesulfonamide,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Dronedarone HCl Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel , sodium channel and calcium channel , used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).
In vitro

Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold)\u2009=\u2009-40 mV with IC50 value of 0.4 μM, whereas at V (hold)\u2009=\u2009-80 mV, Dronedarone (10 μM) blocks only 20\u2009% of the current.

In vivo

Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction.
Cell Data

cell lines：Human breast cancer cells MDA-MB-468

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

SR33589 | N-​[2-​butyl-​3-​[4-​[3-​(dibutylamino)​propoxy]​benzoyl]​-​5-​benzofuranyl]​-methanesulfonamide,hydrochloride (1:1)

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

BLOCKER

作用メカニズム

Voltage-gated L-type calcium channel blocker

名前と識別子

• 異性体SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC.Cl
• WGKドイツ: 3
• 分子量: 593.22
• Reaxy-Rn: 8380427
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8380427&ln=

関連ターゲット（人間）

KCNA5 Tclin Potassium voltage-gated channel subfamily A member 5 (1 Activities)

Discover Target: KCNA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: 144 °C

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 141625-93-6, the molecular formula is C31H45ClN2O5S, and the molecular weight is 593.22 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.