DSP-4 - ≥98%(HPLC) , CAS No.40616-75-9

CAS: 40616-75-9 Cat. No.: D288182 分子式: C₁₁H₁₅BrClN·HCl 分子量: 313.06

GRADE & PURITY ≥98%(HPLC)

Synonyms

1-Hydroxy-2,3-dimethoxy-10-methyl-10H-acridin-9-one | N-(2-Bromobenzyl)-2-chloro-N-ethylethan-1-amine hydrochloride | DSP-4 (hydrochloride) | HY-103210 | D81991 | EU-0100299 | SMR000326817 | N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, >=98

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

DSP-4 hydrochloride (Neurotoxin DSP 4 hydrochloride) is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats, can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC)

Specifications

同義語

1-Hydroxy-2,3-dimethoxy-10-methyl-10H-acridin-9-one | N-(2-Bromobenzyl)-2-chloro-N-ethylethan-1-amine hydrochloride | DSP-4 (hydrochloride) | HY-103210 | D81991 | EU-0100299 | SMR000326817 | N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, >=98

仕様と純度

≥98%(HPLC)

生化学的・生理学的メカニズム

Adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%(HPLC)

名前と識別子

• パブケム・シド: 504766821
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504766821
• カノニカル・スマイル: CCN(CCCl)CC1=CC=CC=C1Br.Cl
• IUPAC Name: N-[(2-bromophenyl)methyl]-2-chloro-N-ethylethanamine;hydrochloride
• InChIKey: NDDRNRRNYOULND-UHFFFAOYSA-N
• INCHI: 1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
• 異性体SMILES: CCN(CCCl)CC1=CC=CC=C1Br.Cl
• WGKドイツ: 3
• RTECS: DP1726100
• 代替CAS番号: 62078-98-2
• 分子量: 313.06

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives
      • Subclass Phenylmethylamines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: Phenylmethylamines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylmethylamines
• Alternative Parents: Benzylamines Bromobenzenes Aralkylamines Aryl bromides Trialkylamines Organopnictogen compounds Organochlorides Organobromides Organic chloride salts Hydrocarbon derivatives Alkyl chlorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzylamine - Phenylmethylamine - Bromobenzene - Aralkylamine - Halobenzene - Aryl bromide - Aryl halide - Tertiary aliphatic amine - Tertiary amine - Alkyl chloride - Organonitrogen compound - Organochloride - Organobromide - Organohalogen compound - Organic salt - Organic chloride salt - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Amine - Alkyl halide - Aromatic homomonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as phenylmethylamines. These are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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nfo Endonuclease 4 (425 Activities)

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作用メカニズム

化学的性質と物理的性質

• 溶解度: Soluble in DMSO, the highest concentration (mg/mL): 125, the highest concentration (mM):399.28(Need ultrasonic)
• 分子量: 313.060 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 310.984 Da
• Monoisotopic Mass: 310.984 Da
• Topological Polar Surface Area: 3.200 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 154.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

参考文献

1. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan.  (2022)  Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors.  PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,      [PMID:36462602] [10.1016/j.pnpbp.2022.110689]