Duocarmycin TM - 10mM in DMSO , CAS No.157922-77-5

CAS: 157922-77-5 Cat. No.: D656393 分子式: C₂₅H₂₃ClN₂O₅ 分子量: 466.91 PubChem CID: 394851

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic . Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.

In Vitro

Duocarmycin TM (60 μM; 4 d; BJAB and WSU-DLCL2 cells) is a cytotoxic agent that inhibits the proliferation of tumor cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: BJAB and WSU-DLCL2 cells Concentration: 60 μM Incubation Time: 4 days Result: Inhibited the proliferation of tumor cells with IC 50 values of 0.153 μM and 0.079μM for BJAB and WSU-DLCL2 cells, respectively.

IC50& Target:Duocarmycins

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic . Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

• 異性体SMILES: COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3C[C@H](C4=C3C=C(C5=CC=CC=C54)O)CCl)OC)OC
• PubChem CID: 394851
• NSC番号: 698927
• 分子量: 466.91