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DY-46-2 - ≥98% , CAS No.1105110-83-5
注文可能
グレード＆純度 ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
このグレードを選ぶ理由
≥98% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
保管・配送
Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。
品質書類
SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。
文献的裏付け
クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
概要
DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC 50 value of 0.39 μM
In Vitro
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has an inhibitory activity of DNMT3A with an IC 50 value of 0.39 μM, which increases linearly with DNA concentration (IDT-01). DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has inhibitory activity against DNMT1, DNMT3B and G9a with IC 50 values of 13.0 μM, 105 μM and ＞500 μM, respectively. DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has cell viability in cancer cells with IC 50 values of 0.7 μM, 0.3 μM, 0.7 μM, 0.5 μM, 2.1 μM, 1.7 μM and 91 μM for THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell, respectively. DY-46-2 (0.1-100 μM, 24, 48 and 72 h) markedly inhibits the proliferation of cancer cells and shows low cytotoxicity in peripheral blood mononuclear cells (PBMCs). DY-46-2 (1 μM, 72 h) obviously decreases DNMT3A protein levels, as well as reactive expression of a silenced TSG (p53) in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell Concentration: 0.1-100 μM Incubation Time: 24, 48 and 72 h Result: Had remarkable inhibitory potency in the dose- and time-dependent manners and no cytotoxicity in non-tumoral PBMCs (IC 50 >100 μM). Cell Proliferation AssayCell Line: THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell Concentration: 0.1-100 μM Incubation Time: 24, 48 and 72 h Result: Exhibited high anti-proliferative activity with a micromolar range cytotoxicity in all cancer cells. Western Blot AnalysisCell Line: HCT116 cells Concentration: 1 μM Incubation Time: 72 h Result: Decreased DNMT3A and p53 protein levels in the HCT116 cells, apparently sufficient to reactive expression of a silenced TSG (p53).
Form:Solid
IC50& Target:DNMT3A 0.39 μM (IC 50 )
仕様
仕様と純度
≥98%
生化学的・生理学的メカニズム
DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC 50 value of 0.39 μM.
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
純度
≥98%
名前と識別子
分子量
446.48
ドキュメント
📋 安全データシート（SDS）
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
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