(E)-[6]-Dehydroparadol - ≥95% , CAS No.878006-06-5

CAS: 878006-06-5 Cat. No.: D649327 分子式: C₁₇H₂₄O₃ 分子量: 276.37 PubChem CID: 6438480

GRADE & PURITY ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol , is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells

In Vitro

(E)-[6]-Dehydroparadol (M15) (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC 50 s of 43.02 and 41.59 µM, respectively. (E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(E)-[6]-Dehydroparadol (compound 19) (5 µM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Nrf2

Specifications

仕様と純度

≥95%

生化学的・生理学的メカニズム

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol ( HY-14616 ), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ACTIVATOR

純度

≥95%

名前と識別子

• 異性体SMILES: CCCCCCCC(=O)/C=C/C1=CC(=C(C=C1)O)OC
• PubChem CID: 6438480
• 分子量: 276.37

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : ≥ 140 mg/mL (506.57 mM)
• 分子量: 276.400 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 276.173 Da
• Monoisotopic Mass: 276.173 Da
• Topological Polar Surface Area: 46.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 299.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 878006-06-5, the molecular formula is C17H24O3, and the molecular weight is 276.37 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.