≥98% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。
SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。
クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
E1231 is an orally active activator of Sirtuin 1 ( SIRT1 ) ( EC 50 =0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (K D =9.61 μM) and deacetylated liver X receptor-alpha ( LXRα ), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE -/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases
In Vitro
E1231 (0.1-10 μM; 18 h) promotes cholesterol efflux and inhibits lipid accumulation in RAW 264.7 cells. E1231 (10 μM; 6 h) significantly increases deacetylation of Doxo-induced p53 in HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
E1231 (40 mg/kg; po; once daily for 7 days) regulates cholesterol and lipid metabolism in Golden hamsters fed with HFD diet . E1231 (25, 50, and 100 mg/kg, in 0.5% CMC-Na; po; once daily for 12 weeks) reduces atherosclerosis development, without hepatotoxicity ornephrotoxicity in ApoE -/- mice fed with atherogenic diet . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: HFD-diet Golden hamsters (80-90 g) Dosage: 40 mg/kg Administration: PO; once daily for 7 days Result: Increased SIRT1 protein expression but not SIRT3, SIRT6, or SIRT7. And reduced liver and serum cholesterol in hamsters. Animal Model: Atherogenic diet ApoE -/- mice Dosage: 25, 50, and 100 mg/kg Administration: PO; once daily for 12 weeks Result: Modulated plaque composition, immunofluorescence staining. And reduced CD68 positive areas while increasing ABCA1 expression in the aortic sinus.
Form:Solid
IC50& Target:SIRT1 0.83 μM (EC 50 )
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
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| 溶解度 | DMSO : 100 mg/mL (275.17 mM; Need ultrasonic) |
|---|---|
| 分子量 | 363.400 g/mol |
| XLogP3 | 2.100 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 363.158 Da |
| Monoisotopic Mass | 363.158 Da |
| Topological Polar Surface Area | 66.700 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 561.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
