EC-17 disodium salt - ≥96% , CAS No.910661-33-5

CAS: 910661-33-5 Cat. No.: E646854 分子式: C₄₂H₃₄N₁₀Na₂O₁₀S 分子量: 916.82 PubChem CID: 167994876

GRADE & PURITY ≥96%

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

概要

EC-17 (disodium salt) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The peak excitation and emission wavelengths of EC-17 are 470/520 nm.

In Vitro

EC-17 contains the fluorescein fluorochrome and has a spectral wavelength of 490-530?nm. EC-17 is synthesized by a folate (vitamin B9) and fluorescein isothiocyanate (FITC) conjugated through an ethylenediamine spacer to produce folate-FITC, with a molecular weight of 917?kDa. FITC is a derivative of fluorescein functionalized with an isothiocyanate reactive group. The folate-FITC conjugate forms a negatively charged fluorescent molecule that specifically targets cell-surface FRα and is subsequently internalized into the cytoplasm. The signal-to-background ratio (SBR) of EC-17 for HeLa cells range from 0.97 to 7.32 depending on the molarity and concentration of cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The mean fluorescence signal from the animals injected with EC-17 to be 42,234 ± 12,234?au . Fluorescence microscopy for folate-FITC shows a strong signal in all malignant tumors with FR-α expression and no signal in FR-α–negative malignant or benign lesions. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Folate receptor alpha

Specifications

仕様と純度

≥96%

生化学的・生理学的メカニズム

EC-17 (disodium salt) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The peak excitation and emission wavelengths of EC-17 are 470/520u2009nm.

保管条件

Protected from light,Store at -20°C,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥96%

名前と識別子

• カノニカル・スマイル: [HH].C1C(NC2C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NCCNC(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O)C(=O)O.[Na]
• InChIKey: JQYYDKMXXFQNDP-OSYSSLFZSA-N
• INCHI: 1S/C42H42N10O10S.Na.H2/c43-40-51-35-34(37(57)52-40)48-23(19-47-35)18-46-21-3-1-20(2-4-21)36(56)50-30(38(58)59)11-12-33(55)44-13-14-45-41(63)49-22-5-8-27-26(15-22)39(60)62-42(27)28-9-6-24(53)16-31(28)61-32-17-25(54)7-10-29(32)42;;/h1-10,15-17,23,30,34-35,46-48,53-54H,11-14,18-19H2,(H,44,55)(H,50,56)(H,58,59)(H2,45,49,63)(H3,43,51,52,57);;1H/t23?,30-,34?,35?;;/m0../s1
• PubChem CID: 167994876
• 分子量: 916.82

化学的性質と物理的性質

• 溶解度: DMSO : 40 mg/mL (43.63 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

よくある質問

What is the purity of this product?

This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 910661-33-5, the molecular formula is C42H34N10Na2O10S, and the molecular weight is 916.82 g/mol. InChIKey JQYYDKMXXFQNDP-OSYSSLFZSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.