Ec2la - Moligand™, ≥98%(HPLC) , Allosteric modulator of CB 2 receptor, CAS No.2244579-87-9, Allosteric modulator of CB 2 receptor

CAS: 2244579-87-9 Cat. No.: E288545 分子式: C₂₁H₂₄BrFN₂O₂ 分子量: 435.33

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide | CB2R PAM

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

同義語

N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide | CB2R PAM

仕様と純度

Moligand™, ≥98%(HPLC)

生化学的・生理学的メカニズム

CB2receptor positive allosteric modulator. EnhancesCP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ALLOSTERIC MODULATOR

作用メカニズム

Allosteric modulator of CB 2 receptor

純度

≥98%(HPLC)

名前と識別子

• パブケム・シド: 504773499
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504773499
• カノニカル・スマイル: CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3
• IUPAC Name: N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide
• InChIKey: NSGDYZCDUPSTQT-UHFFFAOYSA-N
• INCHI: 1S/C21H24BrFN2O2/c1-14-18(22)13-25(12-15-8-10-17(23)11-9-15)21(27)19(14)24-20(26)16-6-4-2-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,24,26)
• 異性体SMILES: CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3
• 分子量: 435.33
• Reaxy-Rn: 33991973
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33991973&ln=

関連ターゲット（人間）

CNR2 Tchem Cannabinoid receptor 2 (2 Activities)

Discover Target: CNR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

Discover Target: CNR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)

Discover Target: CNR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 8.71, Max Conc. mM: 20
• 分子量: 435.300 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 434.101 Da
• Monoisotopic Mass: 434.101 Da
• Topological Polar Surface Area: 49.400 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 630.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1