Edasalonexent - 10mM in DMSO , Nuclear factor NF-kappa-B complex inhibitor, CAS No.1204317-86-1, Nuclear factor NF-kappa-B complex inhibitor

CAS: 1204317-86-1 Cat. No.: E654643 分子式: C₃₁H₄₂N₂O₃ 分子量: 490.68 PubChem CID: 44626120

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

In Vitro

Edasalonexent is an orally administered small molecule in which salicylic acid and docosahexaenoic acid (DHA) are covalently conjugated through an ethylenediamine linker and that is designed to synergistically leverage the ability of both of these compounds to inhibit NF-κB. Edasalonexent significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever duchenne muscular dystrophy (DMD) model. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The treatment of mdx mice with Edasalonexent for 20 weeks results in reduced susceptibility of the extensor digitorum longus muscle to eccentric contraction-induced injury . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NF-κB

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

保管条件

Protected from light,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

作用メカニズム

Nuclear factor NF-kappa-B complex inhibitor

製品の性質

• ALogP: 7.1

名前と識別子

• 異性体SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCNC(=O)C1=CC=CC=C1O
• 代替CAS番号: 1204317-86-1
• PubChem CID: 44626120
• MeSH用語: CAT-1004;edasalonexent
• 分子量: 490.68