Efaproxiral (RSR13) - Moligand™,10mM in DMSO , Hemoglobin HbA negative modulator, CAS No.131179-95-8, Hemoglobin HbA negative modulator

CAS: 131179-95-8 Cat. No.: E656594 分子式: C₂₀H₂₃NO₄ 分子量: 341.40

グレード＆純度 Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy

In Vitro

Efaproxiral binds to only one pair of symmetry-related sites in the Hb central water cavity. Efaproxiral readily crosses the red cell membrane in the presence of serum albumin solutions. Efaproxiral is not inhibited from entering erythrocytes in the presence of an anion-channel blocking agent (DIDS). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Efaproxiral (150 mg/kg, i.p.) increase tumor oxygenation，and increase the tumor growth inhibition of radiotherapy over 5 days of treatment. Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumorsMCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C3H/HEJ mice (18–20 g), with radiation-induced fibrosarcoma tumor (RIF-1) cells xenograftDosage: 150 mg/kg Administration: Intraperitoneal injection; prior to X Irradiation (4 Gy/day), for 5 days Result: Significantly increased tumor oxygenation by 8.4 to 43.4 mmHg within 5 days, with maximum increases at 22–31 minutes after treatment.

IC50& Target:haemoglobin (Hb)

仕様

仕様と純度

Moligand™,10mM in DMSO

生化学的・生理学的メカニズム

Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

NEGATIVE MODULATOR

作用メカニズム

Hemoglobin HbA negative modulator

製品の性質

ALogP

3.6

名前と識別子

異性体SMILES

CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(C=C2)OC(C)(C)C(=O)O)C

分子量

341.40

よくある質問

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 131179-95-8, the molecular formula is C20H23NO4, and the molecular weight is 341.40 g/mol.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.