Name: Efonidipine - Moligand™, 10mM in DMSO , Channel blocker of Ca v3.2, CAS No.111011-63-3, Channel blocker of Ca v3.2
Brand: Aladdin Scientific
SKU: E420611
Availability: InStock

Efonidipine - Moligand™, 10mM in DMSO , Channel blocker of Ca v3.2, CAS No.111011-63-3, Channel blocker of Ca v3.2

CAS: 111011-63-3 Cat. No.: E420611 分子式: C₃₄H₃₈N₃O₇P 分子量: 631.66

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Efonidipine - Moligand™, 10mM in DMSO CAS No(111011-63-3) by Aladdin Scientific

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注文可能

グレード＆純度 Moligand™ ? 10mM in DMSO

Synonyms

(+/-)-EFONIDIPINE | 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | NCGC00182046-01 | 1-tert-butoxycarbonyl-piperidine-4-carboxaldehyde | DB09235 | 2-[

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要仕様製品の性質名前と識別子ドキュメント詳細データ Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

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このグレードを選ぶ理由

Moligand™, 10mM in DMSO Moligand™ ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。

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保管・配送

Store at -80°C Dry ice packs + Cold packs に出荷。正確な仕様については、ロット固有の COA をご確認ください。

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品質書類

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文献的裏付け

クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。

概要

Information

Efonidipine Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.

Targets

T-type calcium channel

In vitro

Although efonidipine is not a specific T-type calcium channe (TTCC) blocker as it could also block L-type calcium channe (LTCC), its efficacy in blocking TTCC is much greater than that of LTCC. Efonidipine exerts an inhibitory effect on aldosterone synthesis and secretion in a human adrenocortical cell line (H295R), an effect that is mediated, at least in part, by suppression of 11-β-hydroxylase and aldosterone synthase expression. Efonidipine also suppresses both Ang II- and K+-induced aldosterone secretion, but it blocks the latter at much lower concentrations than the former.

In vivo

Efonidipine could provide broader beneficial effects including the heart, liver, and plasma, and antioxidant in iron-overload condition in both WT(muβ^+⁄+) and HT(muβ^{th-3 ⁄+},) mice.

Cell Research(from reference)

Cell lines：The NCI-H295R human adrenocortical cell line (H295)

Concentrations：0.3 μM and 3 μM

Incubation Time：24 h

仕様

同義語

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

CHANNEL BLOCKER

作用メカニズム

Channel blocker of Ca v3.2

製品の性質

ALogP

4.956

hba_count

HBD数

回転可能な結合

名前と識別子

パブケム・シド

528769932

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/528769932

カノニカル・スマイル

CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5

IUPAC Name

2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

InChIKey

NSVFSAJIGAJDMR-UHFFFAOYSA-N

INCHI

1S/C34H38N3O7P/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45/h5-17,20,31,35H,18-19,21-23H2,1-4H3

異性体SMILES

CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5

分子量

631.66

Reaxy-Rn

5903282

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5903282&ln=

ドキュメント

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✅ 分析証明書（COA）

ロット固有の品質データ。ロット番号を入力して、正確な COA を取得してください。

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📊 データシート

製品仕様と用途のクイックリファレンス概要。

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🔬 仕様書

このグレードの完全な品質特性と合格基準。

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詳細データ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 分類 Benzene and substituted derivatives
    - Subclass Phenylmethylamines

Kingdom	Organic compounds
Superclass	Benzenoids
分類	Benzene and substituted derivatives
Subclass	Phenylmethylamines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylbenzamines
Alternative Parents	Dihydropyridinecarboxylic acids and derivatives Nitrobenzenes Aniline and substituted anilines Benzylamines Dialkylarylamines Nitroaromatic compounds Phosphonic acid diesters Aralkylamines Phosphonic acid esters Vinylogous amides Enoate esters Amino acids and derivatives Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Dialkylamines Organic oxoazanium compounds Enamines Monocarboxylic acids and derivatives Organic zwitterions Organophosphorus compounds Carbonyl compounds Organic oxides Hydrocarbon derivatives Organopnictogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenylbenzamine - Dihydropyridinecarboxylic acid derivative - Nitrobenzene - Benzylamine - Nitroaromatic compound - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Dihydropyridine - Phosphonic acid diester - Aralkylamine - Hydropyridine - Phosphonic acid ester - Organophosphonic acid derivative - Vinylogous amide - Alpha,beta-unsaturated carboxylic ester - Enoate ester - C-nitro compound - Carboxylic acid ester - Amino acid or derivatives - Tertiary amine - Organic nitro compound - Allyl-type 1,3-dipolar organic compound - Azacycle - Secondary amine - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid derivative - Organic 1,3-dipolar compound - Secondary aliphatic amine - Oxacycle - Organic oxoazanium - Enamine - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic zwitterion - Amine - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Organophosphorus compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
説明	This compound belongs to the class of organic compounds known as phenylbenzamines. These are aromatic compounds consisting of a benzyl group that is N-linked to a benzamine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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DMSO（mg / mL）最大溶解度	100
DMSO（mM）最大溶解度	158.3130165
分子量	631.700 g/mol
XLogP3	5.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	10
Exact Mass	631.245 Da
Monoisotopic Mass	631.245 Da
Topological Polar Surface Area	123.000 Å²
Heavy Atom Count	45
Formal Charge	0
Complexity	1170.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1