Elimusertib hydrochloride - Moligand™, ≥98% , CAS No.1876467-74-1(free base)

CAS: 1876467-74-1(free base) Cat. No.: E414104 分子式: C₂₀H₂₂ClN₇O

GRADE & PURITY Moligand™, ≥98%

Synonyms

BAY 1895344 hydrochloride | BAY-1895344 HCl | 2-​[(3R)​-​3-​methyl-​4-​morpholinyl]​-​4-​(1-​methyl-​1H-​pyrazol-​5-​yl)​-​8-​(1H-​pyrazol-​3-​yl)​-1,​7-​Naphthyridine hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Information

Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally availableATRinhibitor with an IC50 of 7 nM.

Targets

ATR (Cell-free assay) 7 nM

In vitro

BAY 1895344 is shown to be a very potent and highly selective ATR inhibitor (IC50 = 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibits hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM).

In vivo

BAY 1895344 reveals significantly improved aqueous solubility, bioavailability across species and no activity in the hERG patch-clamp assay. It also demonstrates very promising efficacy in monotherapy in DNA damage deficient tumor models as well as combination treatment with DNA damage inducing therapies. BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models.

Specifications

同義語

BAY 1895344 hydrochloride | BAY-1895344 HCl | 2-​[(3R)​-​3-​methyl-​4-​morpholinyl]​-​4-​(1-​methyl-​1H-​pyrazol-​5-​yl)​-​8-​(1H-​pyrazol-​3-​yl)​-1,​7-​Naphthyridine hydrochloride

仕様と純度

Moligand™, ≥98%

生化学的・生理学的メカニズム

Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

純度

≥98%

関連ターゲット（人間）

ATR Tchem Serine/threonine-protein kinase ATR (1 Activities)

Discover Target: ATR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR (1 Activities)

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 82 mg/mL (199.08 mM); Water: 82 mg/mL (199.08 mM); Ethanol: 82 mg/mL (199.08 mM)
• 感度: Moisture sensitive

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1876467-74-1(free base), the molecular formula is C20H22ClN7O.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.