ELN484228 - 10mM in DMSO , CAS No.312-63-0

CAS: 312-63-0 Cat. No.: E423219 分子式: C₁₂H₁₀FNO₂S 分子量: 251.28 EC番号: 667-877-5

GRADE & PURITY 10mM in DMSO

Synonyms

N-(4-fluorophenyl)benzenesulfonamide|312-63-0|ELN484228|4'-fluorobenzenesulfonanilide|NSC164389|ELN 484228|Cambridge id 5265852|CBDivE_015342|CHEMBL367580|SCHEMBL2568291|DTXSID40304155|BCP28956|MFCD00091019|s6798|STK401855|AKOS000383212|N-(4-Fluoro-phenyl

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

ELN484228 is a cell-permeable blocker that targetsα-synuclein, a key protein in Parkinson’s disease.

Specifications

同義語

N-(4-fluorophenyl)benzenesulfonamide | 312-63-0 | ELN484228 | 4'-fluorobenzenesulfonanilide | NSC164389 | ELN 484228 | Cambridge id 5265852 | CBDivE_015342 | CHEMBL367580 | SCHEMBL2568291 | DTXSID40304155 | BCP28956 | MFCD00091019 | s6798 | STK401855 | AKOS000383212 | N-(4-Fluoro-phenyl

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

ELN484228 is a cell penetrant α-synuclein ligand that rescues of α-synuclein induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction. ELN484228 reverses a-synuclein induced impairment of phagocytosis and protects do

保管条件

Protected from light,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• パブケム・シド: 528764345
• カノニカル・スマイル: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)F
• IUPAC Name: N-(4-fluorophenyl)benzenesulfonamide
• InChIKey: AZORQGXJAXEIGC-UHFFFAOYSA-N
• INCHI: 1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H
• 異性体SMILES: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)F
• 分子量: 251.28
• Reaxy-Rn: 2121725
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2121725&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives
      • Subclass Sulfanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: Sulfanilides
• Intermediate Tree Nodes: Not available
• Direct Parent: Sulfanilides
• Alternative Parents: Benzenesulfonamides Benzenesulfonyl compounds Fluorobenzenes Organosulfonamides Aryl fluorides Aminosulfonyl compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzenesulfonamide - Sulfanilide - Benzenesulfonyl group - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Organosulfonic acid amide - Aminosulfonyl compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Organosulfur compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Aromatic homomonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as sulfanilides. These are organic aromatic compounds containing a sulfanilide moiety, with the general structure RS(=O)(=O)NC1=CC=CC=C1.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

作用メカニズム

化学的性質と物理的性質

• 感度: light sensitive
• 分子量: 251.280 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 251.042 Da
• Monoisotopic Mass: 251.042 Da
• Topological Polar Surface Area: 54.600 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 325.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1