EN219 - ≥98% , CAS No.380351-29-1

CAS: 380351-29-1 Cat. No.: E651926 分子式: C₁₇H₁₃Br₂ClN₂O 分子量: 456.56

グレード＆純度 ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Application

230

概要

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination

In Vitro

EN219 (1 μM; 90 min) interacts with RNF114 C8, TUBB1 C201, HSPD1 C442, and HIST1H3A C97 demonstrated by isotopic tandem orthogonal proteolysisABPP (isoTOP-ABPP) analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:RNF114 470 nM (IC 50 )

仕様

仕様と純度

≥98%

生化学的・生理学的メカニズム

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.

保管条件

Store at 2-8°C,Protected from light,Desiccated

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

カノニカル・スマイル

ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O

分子量

456.56

化学的性質と物理的性質

• 溶解度: DMSO : 65 mg/mL (142.37 mM; Need ultrasonic)