EN460 - 10mM in DMSO , CAS No.496807-64-8

CAS: 496807-64-8 Cat. No.: E655310 分子式: C₂₂H₁₂ClF₃N₂O₄ 分子量: 460.79 PubChem CID: 1016023

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 ( IC 50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.

In Vitro

Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 ( IC 50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

C1=CC=C(C=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC(=C(C=C4)Cl)C(=O)O)C(F)(F)F

PubChem CID

1016023

分子量

460.79