Enpp-1-IN-14 - ≥99% , CAS No.2687222-59-7

CAS: 2687222-59-7 Cat. No.: E649281 分子式: C₁₅H₂₂ClN₅O₄S 分子量: 403.88

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC 50 value of 32.38 nM for recombinant human ENPP-1 . Enpp-1-IN-14 has anti-tumor activity

In Vivo

Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×10 5 MC38 cells) Dosage: 50 mg/kg Administration: IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site) Result: Significantly inhibited tumor growth.

Form:Solid

IC50& Target:IC 50 : 32.38 nM (recombinant human ENPP-1)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC 50 value of 32.38 nM for recombinant human ENPP-1 . Enpp-1-IN-14 has anti-tumor activity.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 403.88

化学的性質と物理的性質

• 溶解度: DMSO : 9.62 mg/mL (23.82 mM; Need ultrasonic)