Epiboxidine hydrochloride - ≥99% , CAS No.862909-67-9

CAS: 862909-67-9 Cat. No.: E648084 分子式: C₁₀H₁₅ClN₂O 分子量: 214.69

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

概要

Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with K i s of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs , respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418.

In Vitro

Epiboxidine hydrochloride has affinity and functional at central neuronal α4β2 receptors, with K i s of 0.46 and 1.2 in rat and humen. Epiboxidine hydrochloride has activity at ganglionic-type α3β4*-nicotinic receptors of PC12 cells, with a K i of 19. Epiboxidine hydrochloride is much less toxic than Epibatidine. Epiboxidine hydrochloride stimulates sodium-22 influx in PC12 and TE671 cells, with EC 50 s of 0.18 and 2.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Epiboxidine hydrochloride (20 μg/kg; ip; once) treatment shows marked analgetic activity in mice . Epiboxidine hydrochloride (50 and 100 mg/kg; intraperitoneal injected; once) causes marked antinociception as measured in the hot-plate assay. Epiboxidine hydrochloride inhibits [ 3 H]nicotine binding in rat cerebral cortical membranes, with a K i of 0.6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with K i s of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs , respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analo

保管条件

Store at -20°C,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

AGONIST

純度

≥99%

名前と識別子

• 分子量: 214.69