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· · COA & SDS すべての製品に適用 · 在庫品は当日出荷 Etazolate hydrochloride - Moligand™, ≥98%(HPLC) , Allosteric modulator of GABA A receptor β3 subunit, CAS No.35838-58-5, Allosteric modulator of GABA A receptor β3 subunit
グレード＆純度 Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC) Synonyms
SQ 20,009|1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester, monohydrochloride|1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride|Etazolate HCl|ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate hydrochloride|SQ 64442|SQ 20,009; 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride|E 1896|Etazolate hydrochloride [USAN]|Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate monohydrochloride|Etazolate.Hydrochloride|ethyl 1-ethyl-4-(2-(propan-2-ylidene)hydrazinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate hydrochloride|ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate;hydrochloride|SQ 20009|SQ 20009 hydrochloride;SQ20009 hydrochloride;SQ-20009 hydrochloride|Etazolate (hydrochloride)|1H-Pyrazolo[3, 1-ethyl-4-[(1-methylethylidene)hydrazino]-, ethyl ester, monohydrochloride|Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo(3,4-b)pyridine-5-carboxylate monohydrochloride|Etazolate hydrochloride (USAN)|Etazolatehydrochloride|Etazolate hydrochloride|Etazolate hydrochloride, solid|1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester hydrochloride
仕様 同義語
SQ 20,009 | 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester, monohydrochloride | 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride | Etazolate HCl | ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5 もっと見る
仕様と純度
Moligand™, ≥98%(HPLC)
生化学的・生理学的メカニズム
Phosphodiesterase inhibitor, selective for PDE4 (IC50= 2.0μM).
アクションタイプ
ALLOSTERIC MODULATOR
作用メカニズム
Allosteric modulator of GABA A receptor β3 subunit
名前と識別子 カノニカル・スマイル
CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC.Cl
IUPAC Name
ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate;hydrochloride
InChIKey
GQJUGJHJUZSJLZ-UHFFFAOYSA-N
INCHI
1S/C14H19N5O2.ClH/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2;/h7-8H,5-6H2,1-4H3,(H,15,18);1H
異性体SMILES
CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC.Cl
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5840237&ln=
詳細データ Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds 分類 Pyrazolopyridines Subclass Not available Intermediate Tree Nodes Not available Direct Parent Pyrazolopyridines Alternative Parents Pyridinecarboxylic acids Vinylogous amides Pyrazoles Heteroaromatic compounds Carboxylic acid esters Monocarboxylic acids and derivatives Hydrazones Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Pyrazolopyridine - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Pyridine - Azole - Pyrazole - Vinylogous amide - Heteroaromatic compound - Carboxylic acid ester - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Hydrazone - Azacycle - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrochloride - Hydrocarbon derivative - Aromatic heteropolycyclic compound 説明 This compound belongs to the class of organic compounds known as pyrazolopyridines. These are compounds containing a pyrazolopyridine skeleton, which consists of a pyrazole fused to a pyridine. Pyrazole is 5-membered ring consisting of three carbon atoms and two adjacent nitrogen centers. Pyridine is a 6-membered ring with four carbon and one nitrogen atoms. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3 D構造 関連ターゲット（人間） 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 溶解度 Solvent:water, Max Conc. mg/mL: None, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 32.58, Max Conc. mM: 100 分子量 325.790 g/mol XLogP3 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 6 Exact Mass 325.131 Da Monoisotopic Mass 325.131 Da Topological Polar Surface Area 81.400 Ų Heavy Atom Count 22 Formal Charge 0 Complexity 397.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
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