Ethynodiol diacetate - Moligand™, 10mM in DMSO , Progesterone receptor agonist, CAS No.297-76-7, Progesterone receptor agonist

CAS: 297-76-7 Cat. No.: E408955 分子式: C₂₄H₃₂O₄ 分子量: 384.51 EC番号: 206-044-9

グレード＆純度 Moligand™, 10mM in DMSO

Synonyms

8080 CB | 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.
In vitro

Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte.

In vivo

Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

仕様

同義語

8080 CB | 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

AGONIST

作用メカニズム

Progesterone receptor agonist

製品の性質

ALogP

3.9

名前と識別子

異性体SMILES

CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@]4(C#C)OC(=O)C)C

WGKドイツ

3

RTECS

RC8963000

分子量

384.51

Reaxy-Rn

2678817

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2678817&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 30 mg/mL (195.89 mM); Water: Insoluble; Ethanol: Insoluble
• 比旋光度［α］: -72° (C=1,CHCl3)
• 融点（°C）: 130 °C