Evifacotrep - 10mM in DMSO , CAS No.2413739-88-3

CAS: 2413739-88-3 Cat. No.: E656148 分子式: C₁₈H₁₂ClF₄N₅O₂ 分子量: 441.77 PubChem CID: 146448026

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Evifacotrep, a short transient receptor potential channel 5 and 4 ( TRPC5 / TRPC4 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5 / TRPC4 with IC 50 s ≤50 nM

In Vitro

Evifacotrep (1 μM; 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Evifacotrep (30 mg/kg; sc; once daily or twice daily for 10 days) results in reduced urinary albumin excretion on following injury with puromycinaminonucleoside (PAN) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:TRPC5

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Evifacotrep, a short transient receptor potential channel 5 and 4 ( TRPC5 / TRPC4 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5 / TRPC4 with IC 50 s ≤50 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

名前と識別子

異性体SMILES

C1CN(CC2=C1C(=NC=N2)OC3=C(C=C(C=C3)F)C(F)(F)F)C4=C(C(=O)NN=C4)Cl

PubChem CID

146448026

分子量

441.77

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2413739-88-3, the molecular formula is C18H12ClF4N5O2, and the molecular weight is 441.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.