CD2-CD58 interactions stabilize contact between immune cells and target cells and participate in the organization of T-cell and NK-cell immune synapses, amplification of activation signals, and maintenance of effector functions. Loss of CD58 or insufficient CD2 signaling can weaken antitumor ...
Topic
Costimulation
Techniques for detecting, quantifying and localizing antigens and antibodies — ELISA, Western blotting, immunohistochemistry and flow cytometry. Below are the protocols, FAQs and technical articles in our knowledge base tagged with this topic.
2 resources · protocols, FAQs & articles
The TH cell differentiation pathway is one of the most critical regulatory networks in the establishment of adaptive immune responses. Under the combined influence of antigen stimulation, costimulatory signals, and the cytokine microenvironment, naïve CD4+ T cells progressively differentiate ...
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Techniques often explored alongside immunological experiments.