Granzyme A (GZMA) and Granzyme B (GZMB) are serine proteases released by cytotoxic T cells, natural killer cells, and some NKT cells. They are key effector molecules in the perforin–granzyme cytotoxic system. GZMB is mainly associated with caspase-dependent apoptosis, the Bid–mitochondrial ...
Topic
cytotoxic T cells
Techniques for detecting, quantifying and localizing antigens and antibodies — ELISA, Western blotting, immunohistochemistry and flow cytometry. Below are the protocols, FAQs and technical articles in our knowledge base tagged with this topic.
2 resources · protocols, FAQs & articles
The killer T cell-mediated apoptosis pathway mainly refers to the process by which CD8⁺ cytotoxic T lymphocytes (CTLs) recognize abnormal target cells and induce target cell apoptosis through the perforin-granzyme axis, the Fas/FasL death receptor axis, and TNF-related signaling. This pathway ...
Related topics
Techniques often explored alongside immunological experiments.