regioselectivity

Amino groups, amino alcohols, vicinal diamines, and saturated nitrogen-containing heterocycles are widely found in drug molecules and their synthetic intermediates. The synthesis of these structures requires not only the introduction of nitrogen atoms, but also control over the position of ...

Cyclopropylamines combine a three-membered cyclopropane carbon ring and a nitrogen-containing functional group within the same molecule. Cyclopropane possesses high ring strain and distinctive carbon–carbon bond orbital characteristics, while the nitrogen atom can participate in protonation, ...