Spiral ring block

Ganesh A. Kadam, Suparnak Midya, Vitalina Levchenko, Vadym Sham, Pavel K. Mykhailiuk, and Durga P. Hari reported Ring-Expansion of Ketones with [1.1.1]Propellane, published in the Journal of the American Chemical Society, 2026, 148, 388–399, DOI: 10.1021/jacs.5c14022. This study introduces a ...

In the early stages of drug discovery, researchers usually focus first on activity: whether a compound can bind to the target, inhibit enzymatic activity, or produce the desired effect at the cellular level. However, as a project enters lead optimization, the factors that limit further ...