Tumor invasion

Kallikrein-related peptidases regulate the skin barrier, neural plasticity, vascular homeostasis, and reproductive function through limited proteolysis. Dysregulated KLK expression, activation, or inhibition can remodel the extracellular matrix and receptor signaling and contribute to tumors, ...

Research on the cathepsin family is mainly used to elucidate mechanisms involving lysosomal proteolysis, antigen processing, cell death, matrix remodeling, and inflammatory responses. Members such as Cathepsin B, D, K, L, S, and G differ significantly in catalytic type, cellular localization, ...