Forsythin - analytical standard, ≥97% , CAS No.487-41-2

CAS: 487-41-2 Cat. No.: F104482 分子式: C₂₇H₃₄O₁₁ 分子量: 534.55 PubChem CID: 24721571

GRADE & PURITY Analytical standard, ≥97%

Synonyms

Phillyrin | Phillyroside | Phyllyrin | Phillygenin β-D-Glucopyranoside | 4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H | 3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-Glucopyranoside

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Specifications

同義語

Phillyrin | Phillyroside | Phyllyrin | Phillygenin β-D-Glucopyranoside | 4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H | 3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-Glucopyranoside

仕様と純度

analytical standard, ≥97%

保管条件

Store at 2-8°C,Protected from light,Argon charged

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

分析用標準物質

純度

≥97%

名前と識別子

• パブケム・シド: 528775809
• 異性体SMILES: COC1=C(C=C(C=C1)[C@H]2[C@H]3CO[C@@H]([C@H]3CO2)C4=C(C=C(C=C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)OC)OC
• PubChem CID: 24721571
• 分子量: 534.55

化学的性質と物理的性質

• 感度: Moisture sensitive
• 分子量: 534.600 g/mol
• XLogP3: 0.800
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 534.21 Da
• Monoisotopic Mass: 534.21 Da
• Topological Polar Surface Area: 146.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 757.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

参考文献

1. Ying Ju, Chunling Yin, Yan Zhang, Xiangru Meng, Liuchuang Zhao, Leqian Hu.  (2022)  Rapid detection and quality evaluation of Shuang-Huang-Lian injection by ATR-IR and NIR spectroscopy combined with chemometrics.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36283204] [10.1016/j.saa.2022.122008]

2. Xin Guo, Pingping Cao, Xiongfeng Lian, Meng Hu, Jingyi Zhao, Wenjing Shen, Haili Wang, Hailong Yu, Yingzhu Chen.  (2021)  The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:34425100] [10.1016/j.ejphar.2021.174439]

3. Duan Qiong, Li Ruochen, Wang Mingxiao, Cui Zhenting, Zhu Xia, Chen Fanghong, Han Feng, Ma Jianxin.  (2024)  Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:39356318] [10.1007/s00210-024-03481-1]

4. Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu.  (2024)  Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice.  CYTOKINE,      [PMID:38417214] [10.1016/j.cyto.2024.156556]

5. Kaiping Xiang, Bing Wang, Lanying Wang, Yunfei Zhang, Hanzeng Li, Yanping Luo.  (2024)  Oxidative Stress, Oxidative Damage, and Cell Apoptosis: Toxicity Induced by Arecoline in Caenorhabditis elegans and Screening of Mitigating Agents.  Toxins,  16  (8): (352).  [PMID:39195762] [10.3390/toxins16080352]

6. Zhirui Du, Xueqiao Yan, Lin Cheng, Haiyu Shen, Guoguo Zhi, Baojie Li, Qian Yu.  (2025)  Luteolin attenuates experimental dry eye disease via dual modulation of macrophage JAK-STAT signaling and corneal epithelial MAPK pathways.  PHYTOMEDICINE,      [PMID:41005053] [10.1016/j.phymed.2025.157300]

7. Feng Li, Xinrong Fan, Bohao Wang, Jingyang Tong, Menglai Ling, Haibin Tong, Yumei Huang.  (2025)  Phillyrin counters β2 integrin-mediated neutrophil adhesion and chemotaxis to alleviate endotoxin-induced acute lung injury in neonatal rats.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40210127] [10.1016/j.bcp.2025.116934]