G140 - ≥98% , CAS No.2369751-07-3

CAS: 2369751-07-3 Cat. No.: G647730 分子式: C₁₇H₁₆Cl₂N₄O₂ 分子量: 379.24 PubChem CID: 139388865

GRADE & PURITY ≥98%

Synonyms

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone | T015T-010-1 | T015T-010-1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity

In Vitro

G140 (0.1-100 μM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC 50 s of 1.70 and 0.86?μM in human THP1 and primary macrophages, respectively. ?\nG140 (0.1-100 μM; 24 h) inhibits cells viability with a LD 50 of >100 μM in THP1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 14.0 nM (h-cGAS), 442 nM (m-cGAS)

Specifications

同義語

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone | T015T-010-1 | T015T-010-1

仕様と純度

≥98%

生化学的・生理学的メカニズム

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0u2009nM and 442u2009nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• パブケム・シド: 528764570
• カノニカル・スマイル: CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
• IUPAC Name: 1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
• InChIKey: NVPFAXHXXODQRO-UHFFFAOYSA-N
• INCHI: 1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3
• 異性体SMILES: CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
• PubChem CID: 139388865
• 分子量: 379.24

関連ターゲット（人間）

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CGAS Tchem Cyclic GMP-AMP synthase (693 Activities)

Discover Target: CGAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : 250 mg/mL (659.21 mM; Need ultrasonic)