Gap19 TFA - ≥99% , CAS No.G659263

CAS: G659263 Cat. No.: G659263 Molecular Weight: 1275.46

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)

Appearance:Solid

IC50& Target:Cx43 Hemichannel

In Vitro:Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. G

In Vivo:Gap19 TFA (iv; 25mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57/BL6 miceDosage:

Biological Activity:Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)

Specifications

Specifications & Purity

≥99%

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Molecular Weight: 1275.46

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (78.40 mM; Need ultrasonic) H2O : 100 mg/mL (78.40 mM; Need ultrasonic)