Gliclazide - 10mM in DMSO , Sulfonylurea receptor 1, Kir6.2 blocker, CAS No.21187-98-4, Sulfonylurea receptor 1, Kir6.2 blocker

CAS: 21187-98-4 Cat. No.: G408517 Molecular Weight: 323.41 EC Number: 244-260-5

GRADE & PURITY 10mM in DMSO

Synonyms

N-​[[(hexahydrocyclopen​ta[c]​pyrrol-​2(1H)​-​yl)​amino]​carbonyl]​-​4-​methyl-benzenesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Gliclazide Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

N-​[[(hexahydrocyclopen​ta[c]​pyrrol-​2(1H)​-​yl)​amino]​carbonyl]​-​4-​methyl-benzenesulfonamide

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Sulfonylurea receptor 1, Kir6.2 blocker

Product Properties

• ALogP: 1.5

Names and Identifiers

• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
• WGK Germany: 2
• RTECS: YT4500000
• Molecular Weight: 323.41
• Reaxy-Rn: 1657836
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1657836&ln=

Chemical and Physical Properties

• Melt Point(°C): 165.0-169.0℃

References

1. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li.  (2023)  An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods.  Foods,  12  (3): (539).  [PMID:36766067] [10.3390/foods12030539]

2. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei.  (2021)  Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea.  FOOD CHEMISTRY,      [PMID:34536782] [10.1016/j.foodchem.2021.131055]

3. Jiankun Cao, Qing Jiang, Ruixian Li, Qian Xu, Hongli Li.  (2019)  Nanofibers mat as sampling module of direct analysis in real time mass spectrometry for sensitive and high-throughput screening of illegally adulterated sulfonylureas in antidiabetic health-care teas.  TALANTA,      [PMID:31357362] [10.1016/j.talanta.2019.06.066]

4. Lele Wang, Tijie Duan, Yawen Gao, Heqing Liu, Rui Sun, Tong Wu, Jihui Tang.  (2025)  Development and in vitro-in vivo evaluation of a novel sustained-release tablet based on constant-release surface.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.106603]