GLPG2451 - 10mM in DMSO , CAS No.2055015-61-5

CAS: 2055015-61-5 Cat. No.: G654975 分子式: C₁₆H₁₆F₃N₃O₅S 分子量: 419.38 PubChem CID: 124106089

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC 50 of 11.1 nM

In Vitro

GLPG2451 has an EC 50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Cystic fibrosis transmembrane conductance regulator

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC 50 of 11.1 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ACTIVATOR

名前と識別子

• 異性体SMILES: C[C@@H](CNC(=O)C1=C(C=C(C=N1)S(=O)(=O)C2=CC=C(C=C2)OC(F)(F)F)N)O
• 代替CAS番号: 2055015-61-5
• PubChem CID: 124106089
• 分子量: 419.38

関連ターゲット（人間）

CFTR Tclin Cystic fibrosis transmembrane conductance regulator (2 Activities)

Discover Target: CFTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2055015-61-5, the molecular formula is C16H16F3N3O5S, and the molecular weight is 419.38 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.