GNF2133 - Moligand™,≥98% , CAS No.2561414-56-8

CAS: 2561414-56-8 Cat. No.: G646983 分子式: C₂₄H₃₀N₆O₂ 分子量: 434.53

GRADE & PURITY Moligand™, ≥98%

Synonyms

4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

In Vivo

GNF2133 (30 mg/kg; p.o.) shows good oral absorption with oral bioavailability of 22.3%.

GNF2133 (30 mg/kg; p.o.; once a day for 5 days) shows the ability to proliferate β-cells in vivo.

GNF2133 (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion in RIP-DTA mice.

IC50 & Target

DYRK1,DYRK1A(0.0062 μM (IC50)),GSK3β(>50 μM (IC50))

Specifications

同義語

4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide

仕様と純度

Moligand™,≥98%

生化学的・生理学的メカニズム

GNF2133 is a potent and selective DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capa

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 434.53

化学的性質と物理的性質

• 溶解度: DMSO : 4 mg/mL (9.21 mM; ultrasonic and warming and heat to 60°C)

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2561414-56-8, the molecular formula is C24H30N6O2, and the molecular weight is 434.53 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.