Gramine - 10mM in DMSO , CAS No.87-52-5

CAS: 87-52-5 Cat. No.: G408192 分子式: C₁₁H₁₄N₂ 分子量: 174.24 Beilstein Registry Number: 140521 EC番号: 201-749-8

GRADE & PURITY 10mM in DMSO

Synonyms

(1H-indol-3-yl)-N,N-dimethylmethanamine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic recept
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

同義語

(1H-indol-3-yl)-N,N-dimethylmethanamine

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic recept

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• 異性体SMILES: CN(C)CC1=CNC2=CC=CC=C21
• WGKドイツ: 3
• RTECS: NL7525000
• 分子量: 174.24
• Beilstein: 140521
• Reaxy-Rn: 140521
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=140521&ln=

関連ターゲット（人間）

CYP2D6 Tclin Cytochrome P450 2D6 (1 Activities)

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro Ethanol: mg/mL
• 引火点（°F）: 167℃
• 引火点（°C）: 167℃
• 融点（°C）: 132-134°C

参考文献

1. Gen-Qiang Chen, Yan-Fei Xia, Jin-Ming Yang, Zhi-Ping Che, Di Sun, Shen Li, Yue-E Tian, Sheng-Ming Liu, Jia Jiang, Xiao-Min Lin.  (2020)  Controlled synthesis of N, N-dimethylarylsulfonamide derivatives as nematicidal agents.  JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,      [PMID:31773971] [10.1080/10286020.2019.1694513]

2. Zhang Chunhua, Wu Huiqin, Huang Xiaolan, Zhu Zhixin, Luo Huitai, Huang Fang, Lin Xiaoshan.  (2012)  Simultaneous Determination of Toxic Alkaloids in Blood and Urine by HPLC–ESI–MS/MS.  CHROMATOGRAPHIA,  75  (9): (499-511).  [PMID:] [10.1007/s10337-012-2216-6]

3. Lin-Song Teng, Zhen-Dong Ying, Xiao-Han Sun, Hao-Cheng Hou, Shi-Dong Qiu, Peng Liu, Ke-Jing Li, Lei Zhang, Xie-Huang Sheng.  (2025)  Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:40914538] [10.1016/j.cbi.2025.111724]

4. Huiyu He, Rui Wang, Rongbin Nie, Nan Dong.  (2025)  An environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid-phase dispersion extraction combined with HPLC-MS/MS for multiple analysis of pharmaceuticals and personal care products in aquatic organisms.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115146]

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 87-52-5, the molecular formula is C11H14N2, and the molecular weight is 174.24 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.