GW438014A - ≥99% , CAS No.469861-49-2

CAS: 469861-49-2 Cat. No.: G648232 分子式: C₂₂H₁₉N₃O 分子量: 341.4 EC番号: 806-243-6 PubChem CID: 6918627

GRADE & PURITY ≥99%

Synonyms

GW438014A | GW-438014A | GW-438014-A | N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide | GW 438014 A | N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide | GW 438014A | NCGC00387447-01

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents.

In Vivo

GW438014A (10 mg/kg; i.p.; daily, for 7 d) inhibits spontaneous as well as overnight fasting-induced and NPY-induced feeding in rats and in food-deprived genetically obese ob/ob mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: obese ob/ob mice Dosage: 10 mg/kg Administration: intraperitoneal injection; daily, for 7 d Result: Decreased the rate of weight gain in both lean and obese rats.

Form:Solid

Specifications

同義語

GW438014A | GW-438014A | GW-438014-A | N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide | GW 438014 A | N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide | GW 438014A | NCGC00387447-01

仕様と純度

≥99%

生化学的・生理学的メカニズム

GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

純度

≥99%

名前と識別子

カノニカル・スマイル

C1=CC=C(C=C1)CCN2C3=CC=CC=C3N=C2NC(=O)C4=CC=CC=C4

IUPAC Name

N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide

InChIKey

CDUDZZGLFOFINU-UHFFFAOYSA-N

INCHI

1S/C22H19N3O/c26-21(18-11-5-2-6-12-18)24-22-23-19-13-7-8-14-20(19)25(22)16-15-17-9-3-1-4-10-17/h1-14H,15-16H2,(H,23,24,26)

異性体SMILES

C1=CC=C(C=C1)CCN2C3=CC=CC=C3N=C2NC(=O)C4=CC=CC=C4

WGKドイツ

3

PubChem CID

6918627

分子量

341.4

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Benzimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Benzimidazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzimidazoles
• Alternative Parents: Benzamides Benzoyl derivatives N-substituted imidazoles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzamide - Benzimidazole - Benzoic acid or derivatives - Benzoyl - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Azole - Imidazole - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

化学的性質と物理的性質

• 溶解度: DMSO : 250 mg/mL (571.42 mM; Need ultrasonic)
• 分子量: 341.400 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 341.153 Da
• Monoisotopic Mass: 341.153 Da
• Topological Polar Surface Area: 46.900 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 456.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 469861-49-2, the molecular formula is C22H19N3O, and the molecular weight is 341.4 g/mol. InChIKey CDUDZZGLFOFINU-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.