H 151 - Moligand™, 10mM in DMSO , Antagonist of stimulator of interferon response cGAMP interactor 1, CAS No.941987-60-6, Antagonist of stimulator of interferon response cGAMP interactor 1

CAS: 941987-60-6 Cat. No.: H427016 分子式: C₁₇H₁₇N₃O 分子量: 279.34 EC番号: 845-509-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

941987-60-6|1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea|H-151|H 151|N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea|MFCD08026581|H151|CS-0062722|STING antagonist|3-(4-ethylphenyl)-1-(1H-indol-3-yl)urea|H151 pound>>H 151|CHEMBL5179819|SCHEMBL21484988|GTPL10122|BCP2996

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

同義語

941987-60-6 | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea | H-151 | H 151 | N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea | MFCD08026581 | H151 | CS-0062722 | STING antagonist | 3-(4-ethylphenyl)-1-(1H-indol-3-yl)urea | H151 pound>>H 151 | CHEMBL5179819 | SCHEMBL21484988 | GTPL10122 | BCP2996

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to ha

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ANTAGONIST

作用メカニズム

Antagonist of stimulator of interferon response cGAMP interactor 1

名前と識別子

• パブケム・シド: 528764772
• カノニカル・スマイル: CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
• IUPAC Name: 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
• InChIKey: UJZDIKVQFMCLBE-UHFFFAOYSA-N
• INCHI: 1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
• 異性体SMILES: CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
• 分子量: 279.34
• Reaxy-Rn: 33196081
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33196081&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives
      • Subclass N-phenylureas

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: N-phenylureas
• Intermediate Tree Nodes: Not available
• Direct Parent: N-phenylureas
• Alternative Parents: Indoles Substituted pyrroles Heteroaromatic compounds Ureas Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-phenylurea - Indole - Indole or derivatives - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Urea - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

TMEM173 Tchem Stimulator of interferon genes protein (0 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HFF (3142 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

MEF (1005 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 分子量: 279.340 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 279.137 Da
• Monoisotopic Mass: 279.137 Da
• Topological Polar Surface Area: 56.900 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 352.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

参考文献

1. Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang.  (2022)  Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway.  PHARMACOLOGICAL RESEARCH,      [PMID:36435270] [10.1016/j.phrs.2022.106577]

2. Limin Cao, Li Wang, Zhihong Li, Xia Wei, Jinqiu Ding, Chun Zhou, Xia Chen, Zhicheng Huang, Zhugui Shao, Junchen Shen, Hongfei Lou, Keqing Zhao, Yuwei Huang, Yuanqin Yang, Han Liu, Yumeng Sun, Junling Niu, Shan Jiang, Rong Lu, Longhai Tang, Xiaoming Zhang, Haibing Zhang, Yichuan Xiao, Jianfeng Chen, Shixin Ma, Chengjiang Gao, Guangxun Meng, Li Liu, Zhaozhu Qiu, Haopeng Wang, Liufu Deng, Youqiong Ye, Xin-Ming Jia, Huabin Li, Hui Xiao.  (2025)  Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels.  Science Immunology,  10  (108):   [PMID:40577443] [10.1126/sciimmunol.adn1630]