H10 - ≥98%(HPLC) , CAS No.2084811-68-5

CAS: 2084811-68-5 Cat. No.: H288586 分子式: C₂₄H₂₇N₇O₇S 分子量: 557.58

GRADE & PURITY ≥98%(HPLC)

Synonyms

3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

同義語

3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid

仕様と純度

≥98%(HPLC)

生化学的・生理学的メカニズム

PARP14 inhibitor (IC50= 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cellsin

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ACTIVATOR

純度

≥98%(HPLC)

名前と識別子

• カノニカル・スマイル: C1=CC(=CC(=C1)NC(=O)CCC(=O)NCCC2=CN(N=N2)CCNS(=O)(=O)C3=CC=CC(=C3)C(=O)O)C(=O)N
• IUPAC Name: 3-[2-[4-[2-[[4-(3-carbamoylanilino)-4-oxobutanoyl]amino]ethyl]triazol-1-yl]ethylsulfamoyl]benzoic acid
• InChIKey: MUOMSHSMJCWQFH-UHFFFAOYSA-N
• INCHI: 1S/C24H27N7O7S/c25-23(34)16-3-1-5-18(13-16)28-22(33)8-7-21(32)26-10-9-19-15-31(30-29-19)12-11-27-39(37,38)20-6-2-4-17(14-20)24(35)36/h1-6,13-15,27H,7-12H2,(H2,25,34)(H,26,32)(H,28,33)(H,35,36)
• 異性体SMILES: C1=CC(=CC(=C1)NC(=O)CCC(=O)NCCC2=CN(N=N2)CCNS(=O)(=O)C3=CC=CC(=C3)C(=O)O)C(=O)N
• 分子量: 557.58
• Reaxy-Rn: 30590087
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30590087&ln=

作用メカニズム

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 27.88, Max Conc. mM: 50

よくある質問

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2084811-68-5, the molecular formula is C??H??N?O?S, and the molecular weight is 557.58 g/mol. InChIKey MUOMSHSMJCWQFH-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.