Haloperidol - Moligand™, 10mM in DMSO , Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 7 receptor;Antagonist of D 1 receptor;Antagonist of D 2 receptor;Antagon, Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 7 receptor;Antagonist of D 1 receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 re

CAS: 52-86-8 Cat. No.: H408755 分子式: C₂₁H₂₃ClFNO₂ 分子量: 375.86 Beilstein Registry Number: 21(5)2,377 EC番号: 200-155-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

4-​[4-​(4-​chlorophenyl)​-​4-​hydroxy-​1-​piperidinyl]​-​1-​(4-​fluorophenyl)​-1-​butanone

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Haloperidol Haloperidol (Haldol) is an antipsychotic and butyrophenone.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

4-​[4-​(4-​chlorophenyl)​-​4-​hydroxy-​1-​piperidinyl]​-​1-​(4-​fluorophenyl)​-1-​butanone

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Haloperidol (Haldol) is an antipsychotic and butyrophenone.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

AGONIST, ANTAGONIST, CHANNEL BLOCKER, GATING INHIBITOR

作用メカニズム

Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 7 receptor;Antagonist of D 1 receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 re

名前と識別子

• 異性体SMILES: C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
• WGKドイツ: 3
• RTECS: EU1575000
• UN番号: 2811
• 分子量: 375.86
• Beilstein: 21(5)2,377
• Reaxy-Rn: 331267
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=331267&ln=

関連ターゲット（人間）

DRD1 Tclin D(1A) dopamine receptor (5 Activities)

Discover Target: DRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor (106 Activities)

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD4 Tchem D(4) dopamine receptor (46 Activities)

Discover Target: DRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EBP Tchem 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (1 Activities)

Discover Target: EBP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB1 Tchem Multidrug resistance protein 1 (1 Activities)

Discover Target: ABCB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ6 Tchem G protein-activated inward rectifier potassium channel 2 (1 Activities)

Discover Target: KCNJ6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TMEM97 Tchem Sigma intracellular receptor 2 (5 Activities)

Discover Target: TMEM97

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (63 Activities)

Discover Target: SIGMAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor (53 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD5 Tchem D(1B) dopamine receptor (4 Activities)

Discover Target: DRD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A (7 Activities)

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 (1 Activities)

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1D Tclin Alpha-1D adrenergic receptor (2 Activities)

Discover Target: ADRA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor (1 Activities)

Discover Target: ADRA1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1D Tclin 5-hydroxytryptamine receptor 1D (1 Activities)

Discover Target: HTR1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK2 Tclin Potassium channel subfamily K member 2 (1 Activities)

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH1 Tclin Potassium voltage-gated channel subfamily H member 1 (1 Activities)

Discover Target: KCNH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

H1F0 Tchem Histone H1.0 (1 Activities)

Discover Target: H1F0

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (18 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: 148-149.4°C

参考文献

1. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu.  (2023)  Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37406464] [10.1016/j.jpba.2023.115557]

2. Linlin Chen, Xiaofei Hu, Yunrui Xing, Yaning Sun, Mei Hu, Gaiping Zhang.  (2022)  Highly sensitive immunochromatographic assay for simultaneous determination of azaperone and azaperol in pork.  Food Chemistry-X,      [PMID:36478711] [10.1016/j.fochx.2022.100525]

3. Mingqian Song, Changxin Li, Shijia Wu, Nuo Duan.  (2022)  Screening of specific aptamers against chlorpromazine and construction of novel ratiometric fluorescent aptasensor based on metal-organic framework.  TALANTA,      [PMID:36049339] [10.1016/j.talanta.2022.123850]

4. Tianyi Yang, Guang Yue, Yu Ge, Yue Zhang, Peng Xu, Youmei Wang, Bo Li, Bin Di.  (2022)  SCH 23390 inhibits the acquisition of nitrous oxide-induced conditioned place preference and the changes in ERK phosphorylation expression in nucleus accumbens of mice.  NEUROSCIENCE LETTERS,      [PMID:35525502] [10.1016/j.neulet.2022.136674]

5. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen.  (2022)  Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs.  TALANTA,      [PMID:35462249] [10.1016/j.talanta.2022.123485]

6. Linlin Chen, Xiaofei Hu, Yaning Sun, Yunrui Xing, Gaiping Zhang.  (2022)  An ultrasensitive monoclonal antibody-based lateral flow immunoassay for the rapid detection of xylazine in milk.  FOOD CHEMISTRY,      [PMID:35158128] [10.1016/j.foodchem.2022.132293]

7. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang.  (2021)  Successive liquid-phase microextraction of acidic and basic analytes.  ANALYTICA CHIMICA ACTA,      [PMID:35057942] [10.1016/j.aca.2021.339335]

8. Yujiao Yang, Junke Song, NanNan Liu, Guangyi Wei, Shan Liu, Sen Zhang, Nan Jiang, Haiguang Yang, Guanhua Du.  (2021)  Salvianolic acid A relieves cognitive disorder after chronic cerebral ischemia: Involvement of Drd2/Cryab/NF-κB pathway.  PHARMACOLOGICAL RESEARCH,      [PMID:34800628] [10.1016/j.phrs.2021.105989]

9. Libin Wan, Bin Lin, Ruiqin Zhu, Chuixiu Huang, Stig Pedersen-Bjergaard, Xiantao Shen.  (2019)  Liquid-Phase Microextraction or Electromembrane Extraction?.  ANALYTICAL CHEMISTRY,      [PMID:31141346] [10.1021/acs.analchem.9b00946]

10. Hang Mei, Huajing Liu, Qianqian Shang, Ying Dong, Stig Pedersen-Bjergaard, Chuixiu Huang, Xiantao Shen.  (2021)  Organic-solvent-free electromembrane extraction based on semi-interpenetrating polymer networks.  GREEN CHEMISTRY,  23  (4): (1782-1793).  [PMID:] [10.1039/D1GC00148E]

11. Xiao Yu, Xinlin Li, Sunzhao You, Yuhang Shi, Ruiqin Zhu, Ying Dong, Chuixiu Huang.  (2020)  Electromembrane extraction of chlorprothixene, haloperidol and risperidone from whole blood and urine.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:32827905] [10.1016/j.chroma.2020.461480]