Haptoglobin from human plasma, CAS No.9087-69-8

CAS: 9087-69-8 Cat. No.: np001092

グレード＆純度 BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

Accession #

P00738

Endotoxin Concentration

<2.0 EU/mg

概要

An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. 

仕様

Product Name

Haptoglobin from human plasma, CAS No.9087-69-8

同義語

binding peptide | BP | haptoglobin alpha(1S)-beta | haptoglobin alpha(2FS)-beta | Haptoglobin | haptoglobin, alpha polypeptide | haptoglobin, beta polypeptide | HP | HP-1 | hp2-alpha | HP2ALPHA2 | HPA1S | MGC111141 | zonulin

等級

BioReagent

仕様と純度

BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

生化学的・生理学的メカニズム

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also a

エンドトキシン濃度

<2.0 EU/mg

アクセス番号

P00738

予想分子量

Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa

CAS

9087-69-8

分子タイプ

タンパク質

Product Line

生物製品

保管と配送

形状

Salt-free lyophilized solid.

集中

Pre-lyophilization Protein Concentration

再構成

After centrifugation, we suggest addition of de-ionized H2O to approximately the original volume (See COA), followed by gentle mixingto ensure adequate homogenization.

保管条件

Store at -20°C,Avoid repeated freezing and thawing

入荷

Ice chest + Ice pads

安定性と保管

Store at -20℃ long term (>1 year). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.

よくある質問

What is the purity of this product, and how is it determined?

This product is supplied at ≥95% purity, determined by SDS-PAGE. Lot-specific values are stated on the Certificate of Analysis.

What does BioReagent mean?

BioReagent indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

How should this product be stored?

Store at ?20 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 9087-69-8.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.