Haptoglobin, Mixed Type from Human Plasma, CAS No.9087-69-8

CAS: 9087-69-8 Cat. No.: np001093

GRADE & PURITY BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration: See COA

Accession #

P00738

Overview

  An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.

  Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. 

Specifications

Product Name

Haptoglobin, Mixed Type from Human Plasma, CAS No.9087-69-8

Synonyms

Haptoglobin, Mixed Type | binding peptide | BP | haptoglobin alpha(1S)-beta | haptoglobin alpha(2FS)-beta | Haptoglobin | haptoglobin, alpha polypeptide | haptoglobin, beta polypeptide | HP | HP-1 | hp2-alpha | HP2ALPHA2 | HPA1S | MGC111141 | zonulin | BP

Grade

BioReagent

Specifications & Purity

BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration: See COA

Biochemical and Physiological Mechanisms

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also a

Accession #

P00738

Predicted molecular weight

Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa

CAS

9087-69-8

Molecule Type

Protein

Storage and Shipping

Shape

Salt-free lyophilized solid.

Concentration

Pre-lyophilization Protein Concentration: See COA

Reconstitution

After centrifugation, we suggest addition of de-ionized H2O to approximately the original volume (See COA), followed by gentle mixingto ensure adequate homogenization.

Storage

Store at -20°C,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at -20℃ long term (>1 year). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.