HE 3286 - ≥95% , CAS No.1001100-69-1

CAS: 1001100-69-1 Cat. No.: H648599 分子式: C₂₁H₃₀O₃ 分子量: 330.46 EC番号: 880-101-1 PubChem CID: 16739648

GRADE & PURITY ≥95%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

概要

HE 3286 is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. HE 3286 is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. HE 3286 freely penetrates the blood brain barrier in mice. HE 3286 can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis

In Vitro

HE 3286 attenuates NF-κB phosphorylation, but not influences IκB phosphorylation of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages. HE 3286 (100 nM, overnight) partially blocks the activation of IKK, JNK, p38, and ERK of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: LPS-induced murine macrophages Concentration: 100 nM Incubation Time: overnight Result: Attenuated NF-κB phosphorylation. Blocked the activation of IKK, JNK, p38, and ERK partially.

In Vivo

HE 3286 (25-50 mg/kg; oral gavage; daily for 22-49 days) reduces joint inflammation, synovial proliferation, and erosion of DBA/1 Lac male collagen-induced arthritis mice . HE 3286 (40 mg/kg; intraperitoneal injection; daily for 40 days) suppresses inflammation, reduces demyelination and axonal loss, and promotes RGC survival during experimental optic neuritis of experimental autoimmune encephalomyelitis mice. HE 3286 (80 mg/kg; 0-24h) freely penetrates the BBB in male CD-1 mice. HE 3286 (40 mg/kg; gavage; twice-daily for 4 days) increases the numbers of tyrosine hydroxylase-positive cells and decreases the numbers of damaged neurons in Parkinson's disease mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NF-κB

Specifications

仕様と純度

≥95%

生化学的・生理学的メカニズム

HE 3286 is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. HE 3286 is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. HE 3286 freely penetrates the blood

保管条件

Store at 2-8°C,Desiccated

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥95%

名前と識別子

• 異性体SMILES: C[C@]12CC[C@@H](CC1=C[C@@H]([C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C#C)O)C)O)O
• PubChem CID: 16739648
• 分子量: 330.46

化学的性質と物理的性質

• 分子量: 330.500 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 330.219 Da
• Monoisotopic Mass: 330.219 Da
• Topological Polar Surface Area: 60.700 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 630.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 8
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

参考文献

1. Kaili Liu, Jianli Li, Zhiwei Sun, Yuheng Sun, Xuerui Zhang, Yang Sui, Zhongyuan Qu, Xiang Zou.  (2025)  Chelidonine-induced inhibition of FBP1 disrupts M2 macrophage polarization and attenuates breast cancer.  PHYTOMEDICINE,      [PMID:41175579] [10.1016/j.phymed.2025.157451]

2. Yin Xuanying, Qiu Jinmei, Cheng Guowang, Wu Jiaxin, Wang Chen, Zheng Chunye, Huang Shuiqing, Chen Tongkai.  (2025)  Biomimetic nanodelivery system with simultaneous blood–brain barrier-crossing and neuroprotective abilities for anti-parkinsonian therapy.  Chinese Medicine,  20  (1): (1-24).  [PMID:41204267] [10.1186/s13020-025-01239-2]

3. Zhongyuan Qu, Huimin Li, Fajing Qiang, Kaili Liu, Shuang Wu, Jianli Li, Xiang Zou.  (2025)  Regulation of inflammation by Chaihu-Shugan-San: Targeting the IL-17/ NF-κB pathway to combat breast cancer-related depression.  PHYTOMEDICINE,      [PMID:40382939] [10.1016/j.phymed.2025.156836]

よくある質問

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1001100-69-1, the molecular formula is C21H30O3, and the molecular weight is 330.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.