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HP590 - ≥98% , CAS No.H659414
注文可能
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Protected from light,Desiccated
Shipped In
Wet ice
Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
概要
HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM; ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.
Appearance:Solid
IC50& Target:IC50: 27.8 nM (STAT3 luciferase activity)
In Vitro:HP590 (0-40 μM; 72 h) shows anti-proliferative activities to MKN45, AGS, and MGC803 cells. HP590 (0-40 nM; 0-24 h) inhibits STAT3 Tyr 705 and Ser 727 phosphorylation in GC cells, blocks the expression of STAT3 downstream genes (c-Myc and cyclin D1) i
In Vivo:HP590 (oral administration; 25 and 50mg/kg; once daily; 5 w) inhibits GC growth effectively by inhibiting the STAT3 activation and shows better tolerance in GC xenograft model. MCE has not independently confirmed the accuracy of these methods. They
Biological Activity:HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM; ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.
Specifications
仕様と純度
≥98%
保管条件
Store at 2-8°C,Protected from light,Desiccated
入荷
Wet ice
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
純度
≥98%
名前と識別子
| 分子量 | 590.52 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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よくある質問
What are the CAS number, molecular formula and molecular weight?
The CAS Number is H659414, the molecular formula is C29H24F6N4O3, and the molecular weight is 590.52 g/mol.
What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.
How is this product shipped?
This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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