HTL14242 - 10mM in DMSO , CAS No.1644645-32-8

CAS: 1644645-32-8 Cat. No.: H655376 分子式: C₁₆H₈ClFN₄ 分子量: 310.71 PubChem CID: 86763358

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pK i and a pIC 50 of 9.3 and 9.2, respectively HTL14242 can be used for the research of parkinson’s disease .

In Vitro

HTL14242 is stable in rat plasma, inactive at the hERG ion-channel, and has a clean profile in vitro assays of cytotoxicity in HepG2 cells, the TC 50 is >90 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HTL14242 (oral administration; 1, 3, or 10 mg/kg; sacrificed 1 h postdose) emonstrates an excellent, dose-dependent occupancy of mGlu 5 receptors from an oral dose, with an estimated ED 50 of 0.3 mg/kg . HTL14242 (oral administration; 1 mg/ml) exhibits an oral PK Profile, the t 1/2 , AUC inf and F% are 6.5 hours, 3946 ng/h/mL and 80%, respectively in dog . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Dog (PK study) Dosage: 3, 10 and 30 mg/kg Administration: Oral administration; single dose Result: Had a good PK characteristics in dogs.

IC50& Target:mGlu 5

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pK i and a pIC 50 of 9.3 and 9.2, respectively. HTL14242 can be used for the research of parkinson’s disease.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

Product Line

H655376-1ml

名前と識別子

異性体SMILES

C1=CC(=NC=C1F)C2=CC(=NC=N2)C3=CC(=CC(=C3)C#N)Cl

PubChem CID

86763358

MeSH用語

3-chloro-5-(6-(5-fluoropyridin-2-yl)pyrimidin-4-yl)benzonitrile;Heptares 25;HTL14242

分子量

310.71

関連ターゲット（人間）

GRM5 Tchem Metabotropic glutamate receptor 5 (3 Activities)

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1644645-32-8, the molecular formula is C16H8ClFN4, and the molecular weight is 310.71 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.