Factor XIa, CAS No.37203-61-5

CAS: 37203-61-5 Cat. No.: H1443844

グレード＆純度 Bioactive, ActiBioPure™, Native, High Performance, EnzymoPure™, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Accession #

P03951

Bioactivity

See COA

概要

  Prepared from Human Factor XI using Human Factor Xlla. This Xlla was removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor Xlla and High Molecular Weight Kininogen. During activation by Factor Xlla and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces.

  Extinction Coefficient (1%) = 13.1

  The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD. 

仕様

Product Name

Factor XIa, CAS No.37203-61-5

同義語

Human Factor XIa Native Protein | Coagulation Factor XIa, Human Plasma | coagulation factor XIa | plasma thromboplastin antecedent | Coagulation factor XI | F11 | FXI | PTA

等級

ActiBioPure™, Bioactive, High Performance, Native, EnzymoPure™

仕様と純度

Bioactive,ActiBioPure™,Native,High Performance,EnzymoPure™,≥95%(SDS-PAGE),from Human plasma; Protein concentration: See COA

生化学的・生理学的メカニズム

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Catalytic activity: Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. Activity regulation: Inhibited by SERPINA5.

生物活性

See COA

アクセス番号

P03951

予想分子量

160 kDa

CAS

37203-61-5

酵素委員会番号

EC 3.4.21.27

分子タイプ

酵素

Product Line

生物製品

保管と配送

集中

from Human plasma; Protein concentration: See COA

保管条件

Store at -80°C,Avoid repeated freezing and thawing

入荷

Dry ice packs + Cold packs

安定性と保管

Store at -80℃ long term. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

よくある質問

What is ActiBioPure??

ActiBioPure? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, ActiBioPure? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

What does Bioactive mean?

Bioactive indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 37203-61-5.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

What is the purity of this product, and how is it determined?

This product is supplied at ≥95% purity, determined by SDS-PAGE. Lot-specific values are stated on the Certificate of Analysis.