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ITK degrader 1 , CAS No.I1448523
注文可能
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
概要
ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase ( ITK ; DC 50 =3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion ( EC 50 =35.2 nM, Jurkat cells) stimulated by anti-CD3 antibody in vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 , PROTAC linker (black part) Piperidine-C2-piperazine-Boc and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride. E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc.
Specifications
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
DEGRADER
名前と識別子
| 分子量 | 943.02 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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