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JANEX-1 - ≥98% , Tyrosine-protein kinase JAK3 inhibitor, CAS No.202475-60-3, Tyrosine-protein kinase JAK3 inhibitor

CAS: 202475-60-3 Cat. No.: J126663 分子式: C16H15N3O3 分子量: 297.31
COA
JANEX-1 - ≥98% CAS No(202475-60-3) by Aladdin Scientific
注文可能
グレード＆純度 ≥98%
Synonyms
MFCD01862614 | 4-(4'-Hydroxylphenyl)-amino-6,7-dimethoxyquinazoline hydrochloride dihydrate | BDBM50227519 | AC-35236 | HOZUXBLMYUPGPZ-UHFFFAOYSA-N | EX-A2590 | Janex 1 | JANEX-1 | 1J8Q49TR3I | s5903 | 4-((6,7-dimethoxy-4-quinazolinyl)amino)phenol | 4-(6,
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
サイズ
USA
ドイツ (EU)*
価格
個数
5mg
J126663-5mg
3 在庫あり
—
$58.90
10mg
J126663-10mg
3 在庫あり
—
$98.90
50mg
J126663-50mg
3 在庫あり
—
$114.90
Enter a quantity for the sizes you want to add.
バルク / カスタム
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SDS
Safety data
COA
Certificate
DS
データシート
SP
仕様書
概要 仕様 製品の性質 名前と識別子 ドキュメント 詳細データ Taxonomic Classification 3 D構造 関連ターゲット（人間） 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 よくある質問と記事 ソリューション計算機 レビュー
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このグレードを選ぶ理由

≥98% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。

🌡

保管・配送

Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。

📋

品質書類

SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。

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文献的裏付け

クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。

概要

Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Janex-1 has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Janex-1 acts as a potent inhibitor of glioblastoma cell adhesion and migration and is also reported to block thrombin-induced platelet aggregation.
A selective inhibitor of tyrosine kinase activity of JAK3

仕様

同義語
MFCD01862614 | 4-(4'-Hydroxylphenyl)-amino-6,7-dimethoxyquinazoline hydrochloride dihydrate | BDBM50227519 | AC-35236 | HOZUXBLMYUPGPZ-UHFFFAOYSA-N | EX-A2590 | Janex 1 | JANEX-1 | 1J8Q49TR3I | s5903 | 4-((6,7-dimethoxy-4-quinazolinyl)amino)phenol | 4-(6,
仕様と純度
≥98%
生化学的・生理学的メカニズム
Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 μM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases.
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
作用メカニズム
Tyrosine-protein kinase JAK3 inhibitor
純度
≥98%
製品の性質
ALogP
3
名前と識別子
パブケム・シド
508810591
カノニカル・スマイル
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
IUPAC Name
4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
InChIKey
HOZUXBLMYUPGPZ-UHFFFAOYSA-N
INCHI
1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
異性体SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
分子量
297.31
Reaxy-Rn
8154591
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8154591&ln=

ドキュメント

📋 安全データシート（SDS）

危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。

<<<<<<< HEAD SDS をダウンロード → ======= SDS をダウンロード → >>>>>>> release248-p3

✅ 分析証明書（COA）

ロット固有の品質データ。ロット番号を入力して、正確な COA を取得してください。

COA を検索 →

📊 データシート

製品仕様と用途のクイックリファレンス概要。

データシートを見る →

🔬 仕様書

このグレードの完全な品質特性と合格基準。

仕様書を見る →

詳細データ

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Diazanaphthalenes
SubclassBenzodiazines
Intermediate Tree Nodes Quinazolines
Direct ParentQuinazolinamines
Alternative Parents p-Aminophenols  Anisoles  Aniline and substituted anilines  Aminopyrimidines and derivatives  Alkyl aryl ethers  1-hydroxy-2-unsubstituted benzenoids  Imidolactams  Heteroaromatic compounds  Secondary amines  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Quinazolinamine - P-aminophenol - Aminophenol - Anisole - Aniline or substituted anilines - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Aminopyrimidine - Phenol - Monocyclic benzene moiety - Pyrimidine - Benzenoid - Imidolactam - Heteroaromatic compound - Ether - Azacycle - Secondary amine - Amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Aromatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





関連ターゲット（人間）
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TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
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IMPDH2 Tclin Inosine-5'-monophosphate dehydrogenase 2 (1326 Activities)
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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
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PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)
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IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)
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DCK Tchem Deoxycytidine kinase (530 Activities)
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MAPK11 Tchem MAP kinase p38 beta (2785 Activities)
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CSNK1G1 Tchem Casein kinase I gamma 1 (2496 Activities)
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STK3 Tchem Serine/threonine-protein kinase MST2 (3069 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
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Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
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Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK6 Tclin Cyclin-dependent kinase 6 (1724 Activities)
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PRKAG2 Tchem AMP-activated protein kinase, gamma-2 subunit (243 Activities)
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AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 Activities)
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AKT3 Tchem Serine/threonine-protein kinase AKT3 (3157 Activities)
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GRK2 Tchem G-protein coupled receptor kinase 2 (1019 Activities)
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PYGB Tchem Brain glycogen phosphorylase (474 Activities)
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AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)
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RPS6KA4 Tchem Ribosomal protein S6 kinase alpha 4 (2104 Activities)
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ROCK1 Tclin Rho-associated protein kinase 1 (4723 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PKN2 Tchem Protein kinase N2 (1991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSK Tchem Tyrosine-protein kinase CSK (2395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA5 Tchem Ribosomal protein S6 kinase alpha 5 (3355 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKD3 Tchem Protein kinase C nu (2315 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCI Tchem Protein kinase C iota (2821 Activities)
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RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 Activities)
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Prkcb Protein kinase C beta (2 Activities)
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AIRC Multifunctional protein ADE2 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Septin9 Septin-9 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acadvl Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate Type日付商品
E1705128E1705128Certificate of AnalysisJun 15, 2026 J126663
化学的性質と物理的性質
溶解度Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml).
屈折率1.69
沸点（°C）468.10° C
融点（°C）192.17°C
分子量297.310 g/mol
XLogP33.000
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass297.111 Da
Monoisotopic Mass297.111 Da
Topological Polar Surface Area76.500 Ų
Heavy Atom Count22
Formal Charge0
Complexity350.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
よくある質問と記事
JAK/STAT Inhibitors
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
JAK/STAT Inhibitors
JAK/STAT Inhibitors
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
JAK STAT Inhibitors
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