Jaspamycin - ≥98% , CAS No.22242-96-2

CAS: 22242-96-2 Cat. No.: J647143 分子式: C₁₂H₁₂N₄O₅ 分子量: 292.25 PubChem CID: 136670059

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity

Form:Solid

IC50& Target:Trypanosoma brucei PKAR(199-499) 6.5 nM (EC 50 ) Trypanosoma Trypanosoma brucei PKA holoenzyme 8 nM (Kd)

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• カノニカル・スマイル: C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CNC2=O)C#N
• IUPAC Name: 7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• InChIKey: SKDKFLFSBDYEDO-WOUKDFQISA-N
• INCHI: 1S/C12H12N4O5/c13-1-5-2-16(10-7(5)11(20)15-4-14-10)12-9(19)8(18)6(3-17)21-12/h2,4,6,8-9,12,17-19H,3H2,(H,14,15,20)/t6-,8-,9-,12-/m1/s1
• 異性体SMILES: C1=C(C2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=CNC2=O)C#N
• PubChem CID: 136670059
• 分子量: 292.25

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • 分類 Pyrrolopyrimidine nucleosides and nucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• 分類: Pyrrolopyrimidine nucleosides and nucleotides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolopyrimidine nucleosides and nucleotides
• Alternative Parents: Glycosylamines Pentoses Pyrrolo[2,3-d]pyrimidines Pyrimidones Substituted pyrroles Vinylogous amides Heteroaromatic compounds Oxolanes 1,2-diols Secondary alcohols Oxacyclic compounds Nitriles Azacyclic compounds Organic oxides Hydrocarbon derivatives Primary alcohols
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Pyrrolopyrimidine ribonucleoside - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Pyrrolo[2,3-d]pyrimidine - Pyrrolopyrimidine - Pyrimidone - Monosaccharide - Pyrimidine - Substituted pyrrole - Oxolane - Heteroaromatic compound - Vinylogous amide - Pyrrole - 1,2-diol - Secondary alcohol - Carbonitrile - Nitrile - Oxacycle - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Alcohol - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organic oxygen compound - Cyanide - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as pyrrolopyrimidine nucleosides and nucleotides. These are nucleoside derivatives containing a ribose derivative which is n-glycosylated to a pyrrolopyrimidine. Also called deazapurine nucleosides, they are analogs of purine nucleosides with the N atom of the purine being replaced by a C atom at position 7.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : 41.67 mg/mL (142.58 mM; Need ultrasonic)