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JC2-11 - ≥98% , CAS No.937820-89-8
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Protected from light,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4 , absent in melanoma 2 ( AIM 2 ) and non-canonical ( NC ) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 ( p20 ), the cleavage of gasdermin D ( GSDMD ), and the releases of IL-1β and lactate dehydrogenases ( LDH ) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1
In Vivo
JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibits the release of caspase-1 (p20) and IL-1β in non-canonical (NC) inflammatory bodies, and weakens the activation of NC inflammatory bodies of C57BL/6 mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice (8 weeks, female) . Dosage: 250 μg/mouse. Administration: Intraperitoneal injection; single dose. Result: Exhibited inhibitory effect on NC inflammatory body.
Form:Solid
IC50& Target:NLRP3 inflammasome
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4 , absent in melanoma 2 ( AIM 2 ) and non-canonical ( NC ) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 ( p20 ), the cleavage of gasd
Storage
Store at 2-8°C, Protected from light, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
| Molecular Weight | 302.30 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : ≥ 100 mg/mL (330.80 mM) |
|---|
Solution Calculators
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