JNJ-1013 - ≥99% , CAS No.2597343-08-1

CAS: 2597343-08-1 Cat. No.: J647610 分子式: C₄₆H₅₅N₉O₇S 分子量: 878.05

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Application

PROTAC

概要

JNJ-1013 is a potent and selective IRAK1 degrader with an IC 50 s of 72, 443, 1071 nM for IRAK1 , IRAK4 , VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP . JNJ-1013 decreases the expression IRAK1 , p-IKBα, pSTAT3(Tyr705)

In Vitro

JNJ-1013 (Degrader-3; 1.5-10000 nM; 24 h) dose-dependently degrades IRAK1 protein with an DC 50 value of 3 nM.. JNJ-1013 (1 µM) decreased the expression of MG-132 stiyumed IRAK1 in a dose-dependent manner. JNJ-1013 (0.01, 0.03, 0.1, 0.3, 1 µM; 24 h) decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) and increases the expression of cleavaged PARP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HEK293T cells Concentration: 1.5-10000 nM Incubation Time: 24 h Result: Decreased the expression of IRAK1 in a dose-dependent manner.

Form:Solid

IC50& Target:IRAK1 72 nM (IC 50 ) IRAK4 443 nM (IC 50 ) VHL FP 1071 nM (IC 50 )

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

JNJ-1013 is a potent and selective IRAK1 degrader with an IC 50 s of 72, 443, 1071 nM for IRAK1 , IRAK4 , VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP . JNJ-1013 decreases the expression IRAK1 , p-IKBα, pS

保管条件

Protected from light,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

DEGRADER

純度

≥99%

名前と識別子

• 分子量: 878.05

化学的性質と物理的性質

• 溶解度: DMSO : 25 mg/mL (28.47 mM; ultrasonic and warming and heat to 60°C)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2597343-08-1, the molecular formula is C46H55N9O7S, and the molecular weight is 878.05 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.